Alza Corporation

Cygnus, Inc.

Durect Corporation

Therasense, Inc.

Ortho-mcneil Pharmaceutical Corp.

Henkel Ag & Company, Kgaa

Jay Douglas Audett

Robert M Gale

Paul B Foreman

Eric N Silverberg

Allison Luciano

Noel Singh

Michel J N Cormier

Jianye Wen

Janan Jona

Eli J Goldman

Adam Heller

James L Say

Michael F Tomasco

Hyun Brian Cho

Joseph B Phipps

Duane O Yamasaki

Rama V Padmanabhan

Henning Sakslund

Susan E Bailey

Thomas M Stein

Jane Stepic

Pravin L Soni

Xinghang Ma

Michael J N Cormier

A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.

Multilaminate backing construction

A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.

Transdermal nicotine salt delivery system

A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

High enhancer-loading polyacrylate formulation for transdermal applications

Method of making a high enhancer-loading polyacrylate formulation for transdermal applications

A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.

Transdermal analgesic systems with reduced abuse potential

A polyacrylate formulation suitable for delivery of drug through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

An in vivo electrochemical sensor including a working electrode, and an analyte-responsive sensing layer proximate the working electrode. The sensing layer is exposed at an edge of the sensor, wherein the sensor signal is limited, at least in part, by mass transport of analyte to the sensing layer. The sensor is configured and arranged for implantation into the body of a mammal for contact with body fluids of the mammal. The analyte diffuses to the sensing element via the edge of the sensor, thereby restricting mass transport of the analyte to the sensing element. This is because the solution-contacting surface area of the sensor edge is much smaller than an open face of the sensing layer.

Mass transport limited in vivo analyte sensor

Compositions and methods for preventing ovulation in a woman are provided, as well as compositions and methods for female hormone replacement therapy. The compositions can be administered by the use of a transdermal patch. The patch will administer 17-deacetyl norgestimate alone or in combination with an estrogen such as ethinyl estradiol to women.

Transdermal patch and method for administering 17-deacetyl norgestimate

Solubilization enhancer compositions are provided which facilitate transdermal administration of basic drugs from transdermal systems composed of nonpolar adhesive materials. Preferred solubilization enhancer compositions are comprised of liquid, isomeric acid mixtures such as oleic acid dimer. The invention also relates to novel transdermal systems, drug reservoirs, formulations, and methods of drug administration, in which the disclosed solubilization enhancer compositions are used.

Transdermal delivery of basic drugs using nonpolar adhesive systems and

Growing community of inventors

Somerset, NJ, United States of America

Jay Douglas Audett