Ut-battelle, Inc.

Alliance for Sustainable Energy, LLC

Jay D Huenemann

Adam Michael Guss

Joshua R Elmore

Gregg Tyler Beckham

Davinia Salvachua

This disclosure provides a genetically-modified bacterium from the genusthat comprises an exogenous nucleic acid encoding an enoyl-CoA reductase and an exogenous nucleic acid encoding an acyl-CoA reductase that produces medium chain length alcohols. The disclosure further provides methods for producing medium chain alcohols using such genetically-modified bacterium. This disclosure provides a renewable, bio-based production platform for valuable mcl-alcohols that have a wide range of industrial applications. Current production of mcl-alcohols typically occurs through the hydrogenation of plant oils and waxes. This process leads to issues of deforestation and is largely unsustainable. Utilizing waste lignin streams as the carbon source provides a more sustainable feedstock that can be generated from plant waste like corn stover. Along with this, the use of lignin avoids competition with food resources as traditional starch and sugar feedstocks.

Engineered microbes for conversion of organic compounds to medium chain length alcohols and methods of use

This disclosure provides a genetically-modified bacterium from the genusthat produces itaconate or trans-aconitate. The disclosure further provides methods for producing itaconate or trans-aconitate using a genetically-modified bacterium from the genus

Growing community of inventors

Knoxville, TN, United States of America

Jay D Huenemann