Accuray Inc.

Cyberheart, Inc.

Jay Bailey West

John Robinson Dooley

Calvin R Maurer

Petr Jordan

Calvin R Maurer, Jr

Michael J Saracen

Andriy Myronenko

John W Allison

Prashant Chopra

Anuj K Purwar

Hongwu Wang

Christopher A Janko

Dongshan Fu

Warren D Kilby

Gopinath Kuduvalli

Bai Wang

I-Ning Chang

Colin Sims

Neda Sayan

Gregory L Orr

Etienne Lessard

Jin-Wu J Wang

Derek Olender

Thilaka S Sumanaweera

Eric Schnarr

Patrick Maguire

Sohail Sayeh

James Y Wang

Matthew Core

Ed Gardner

Warren Kilby

Robert O'Connell

Chris Janko

Radhika Mohan Bodduluri

Jr Calvin R Maurer

A method of image-guided radiation treatment is described. The method includes processing a first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, wherein part or all of the image data comprises a target of a patient. The method also includes registering the enhanced image with another image to obtain a registration result and tracking the target using the registration result to generate tracking information. The method also includes directing treatment delivery to the target based on the tracking information obtained from the enhanced image.

Image-guided radiation treatment with imaging data using imaging radiation at different energy levels

A method and apparatus for treatment planning using four dimensional imaging data.

Radiation treatment planning using four-dimensional imaging data

Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. The system includes a memory to store a pre-acquired 3D image of the anatomy of interest in a first reference frame and a processor, operative coupled with the memory, to receive, from an ultrasound probe, a set-up ultrasound image of the anatomy of interest in a second reference frame. The processor further to establish a transformation between the first and second reference frames by registering the set-up ultrasound image with the pre-acquired 3D image and receive, from the ultrasound probe, an intrafraction ultrasound image of the anatomy of interest. The processor further to register the intrafraction ultrasound image with the set-up ultrasound image and track motion of the anatomy of interest based on the registered intrafraction ultrasound image.

Tumor tracking during radiation treatment using ultrasound imaging

A method of sequential monoscopic tracking is described. The method includes generating a plurality of projections of an internal target region within a body of a patient, the plurality of projections comprising projection data about a position of an internal target region of the patient. The method further includes generating external positional data about external motion of the body of the patient using one or more external sensors. The method further includes generating, by a processing device, a correlation model between the projection data and the external positional data by fitting the plurality of projections of the internal target region to the external positional data. The method further includes estimating the position of the internal target region at a later time using the correlation model.

Sequential monoscopic tracking

A non-invasive method and system for using 2D angiographic images for radiosurgical target definition uses non-invasive calibration devices and methods to calibrate an angiographic imaging system and a six-parameter registration algorithm to register angiographic images with 3D scan data for radiation treatment planning.

Non-invasive method for using 2D angiographic images for radiosurgical target definition

A method of image-guided radiation treatment is described. The method may include acquiring a pre-treatment image of a patient and generating a first set of image data of part or all of the patient using imaging radiation at a first energy level and a second set of image data of part or all of the patient using imaging radiation at a second energy level. The method may also include processing the first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, and wherein part or all of the image data comprises the target. The method may also include registering the enhanced image with the pre-treatment image to obtain a registration result and tracking movement and position of the target using the registration result to generate tracking information.

A method of image-guided radiation treatment is described. The method may include acquiring digitally reconstructed radiographs (DRRs) of a patient and generating a first set of image data of part or all of the patient using imaging radiation at a first energy level and a second set of image data of part or all of the patient using imaging radiation at a second energy level. The method may also include processing the first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, and wherein part or all of the image data comprises the target. The method may also include registering the enhanced image with the DRRs to obtain a registration result, tracking movement and position of the target using the registration result to generating tracking information.

Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.

Systems and methods for tracking a target volume, e.g., tumor, during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions to cause the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.

Tracking during radiation treatment using ultrasound imaging

A method of image-guided radiation treatment is described. The method may include acquiring digitally reconstructed radiographs (DRRs) of a patient and generating a first set of image data of part or all of the patient using imaging radiation at a first energy level and a second set of image data of part or all of the patient using imaging radiation at a second energy level, wherein the first energy level is an energy level selected within the range of 50-100 kV and the second energy level is an energy level selected within the range of 100-150 kV. The method ma also include processing the first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, and wherein part or all of the image data comprises the target. The method may also include registering the enhanced image with the DRRs to obtain a registration result, tracking movement and position of the target using the registration result to generating tracking information, and directing a treatment delivery beam to the target based on the tracking information obtained from the enhanced image.

A method and apparatus for treatment planning are described.

Treatment planning software and corresponding user interface

Apparatus for generating multi-energy x-ray images and systems and methods for processing and using multi-energy x-ray images are provided for treating a target, e.g., a tumor, for image-guided radiation therapy. An image-guided radiation therapy system is provided including a treatment delivery system, a multi-energy imaging system, and a system processor. The treatment delivery system includes a radiation source configured to generate treatment radiation beams. The multi-energy imaging system is configured to generate a first set of image data of the patient using imaging radiation at a first energy level and a second set of image data of the patient using imaging radiation at a second energy level. The system processor is configured to process the first and second sets of image data to generate an enhanced image of the patient and to direct the treatment delivery system based on information obtained from the enhanced image.

Growing community of inventors

Mountain View, CA, United States of America

Jay Bailey West