The United States Government As Represented by the Department of Veterans Affairs

University of Arkansas

Bioventures, LLC

Jawahar L Mehta

Peter Anthony Crooks

Narsimha Reddy Penthala

Steven Trigwell

Malay K Mazumder

Shraddha Thakkar

Samiran De

Mark M Mazumder

Magomed Khaidakov

Kottayil I Varughese

Yao Dai

Nawab Ali

Rajesh Sharma

Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.

Inhibitors of oxidized low-density lipoprotein receptor 1 and methods of use thereof

An encased stent that discourages restenosis by having a homogenous endothelial cell lining along the inner wall of the stent. The endothelial cell lining may be coated on the stent before the stent is placed in the artery, or the endothelial cell lining may be grown after placement by several factors that encourage such growth and discourage restenosis. The endothelial cells to coat the stent may be genetically modified to enhance the growth of the endothelial cells into a homogeneous lining. The stent has a continuous lining in the form of a multi-layer polymer coating, including a conducting biocorrosion inhibiting layer and a continuous film of polyurethane coupled by a coupling agent to polyethylene glycol. Various drugs and cell factors may be incorporated into the lining, such as anti-thrombin, anti-inflammatory and anti-coagulant drugs, cell cycle inhibitors, and vascular endothelial growth factors.

Encased stent

Growing community of inventors

Little Rock, AR, United States of America

Jawahar L Mehta