Universidad De Zaragoza

Javier Sancho Sanz

Adrián Velazquez Campoy

Nunilo Cremades Casasin

Aurora Martínez Ruiz

Nunilo Cremades Casasín

Adrián Velázquez Campoy

Ángel Pey Rodríguez

Ming Ying

Compounds of the general formula (I) or salts thereof, for use as a pharmaceutical composition for treating infectious diseases, especially for treating diseases caused byare disclosed. Ris an H atom, an X atom or a CXHradical wherein each X can be the same or different and is a halogen selected from F, Cl, Br or I, and m is an integer between 1 and 3; Ris an NOgroup, a COOR' group or an SOR&#x2032; group; R&#x2032; is a hydrogen (H) atom or a C-Calkyl group; and n is an integer between 1 and 5.

Composition for treating infectious diseases

The invention relates to a compound of general formula (I) for use in a pharmaceutical composition for treating infectious diseases caused by. Rand Rare O, S or N, and can be identical or different; Ris O or S; Ris H or a C-Calkyl group; n represents a value between 0 and 3; and Ris an NO, COOR' or SOR&#x2032; radical, where R&#x2032; is a H or a C-Calkyl group.

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The present invention relates to the use of specific types of compounds acting as pharmacological chaperones having a stabilizing activity on the phenylalanine hydroxylase (PAH) enzyme for the prophylaxis and/or treatment of hyperphenylalaninemia (HPA) and phenylketonuria PKU) and diseases, disorders and conditions related thereto. Further, the present invention relates to pharmaceutical compositions containing the compounds according to the present invention as well as to methods of treatment of HPA, in particular, PKU and diseases, disorders and conditions related thereto.

Compositions for the treatment of hyperphenylalaninemia

Use of the general formula compound (I), or any salt thereof, for preparation of a pharmaceutical compound for the treatment of infections illnesses, in particular for the treatment of. Y is NO, COOH or SOH; Z is O, N or S; Xand Xare halogen atoms which may be the same or different; and m and n take values from 0 to 3 and may be equal or different.

Growing community of inventors

Zaragoza, Spain

Javier Sancho Sanz