Abbott Molecular Inc.

Orochem Technologies, Inc.

Abbott Laboratories Corporation

Javier Ramirez

John C Russell

Tracey L Colpitts

Asha Anil Oroskar

Xuejun Zang

Eric L Russell

Stephen Frost

Bhawani Singh

Eric L Russel

John C Russel

Eric Russell

Tracey Colpitis

The present invention relates to rapid, sensitive methods for determining whether a subject is at risk of developing lung cancer or has lung cancer based on certain combinations or biomarkers or biomarkers and biometric parameters.

Methods and marker combinations for screening for predisposition to lung cancer

This invention relates to a method and apparatus or kit for extracting major metabolites of vitamin D from human plasma or serum. More particularly, the invention provides for the extraction from human plasma or serum samples comprising vitamin D metabolites such as 1,25-dihydroxy vitamin D3, 25-hydroxy vitamin D2, and D3 from protein binding, removal of protein and phospholipids, and isolation of the metabolites using a combination of ion-exchange and Lewis acid mechanisms without the requirement to acidify the samples. The method and apparatus of the invention comprise a cartridge or plurality of cartridges comprising at least one protein crash frit, a strong cation exchanged sorbent, and an acidified alumina sorbent to provide higher recoveries of vitamin D metabolites than existing phospholipid depletion plate techniques. Accurately quantifying 1,25-dihydroxy vitamin D3 is useful in differential diagnosis of vitamin D-related diseases and for monitoring vitamin D therapy in patients with chronic renal disease.

Method and apparatus for the extraction of vitamin D metabolites from human plasma

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Round Lake, IL, United States of America

Javier Ramirez