Vertex Pharmaceuticals, Inc.

Aurora Discovery, Incorporated

Javier Humberto Flores

Minh Vuong

Philip Emanuel Salzmann

Alec Tate Harootunian

Todd N Bennett

James Edward Sinclair

Ashvani Singh

Michael Paul Emery

Paul A Negulescu

Fred F VanGoor

Peter J Coassin

Brian Grot

Trang Nguyen

Matthew Charles Wallace

Walter D Niles

Steve Rodems

Ada Silos-Santiago

Jeff Stack

Daniel Hale

Huy Nguyen

Di Bian

Tuong Phan

Disclosed herein are systems and methods for detecting motion of an object, such as the paw of rat. A tag comprising an inductive element and a capacitive element may be attached to the object and the motion detected by monitoring the affect of the tag on a time-varying magnetic field.

Wireless detection of motion

A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an 'Ussing chamber.'

Multiwell assay apparatus and method for determining biological activity of compounds

A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.

Method for sensing levels of conductive liquids

The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling. Liquid transfer to and from multiwell platforms, necessary for assay construction or for the initiation of physiological events in cells, is partitioned among different modules specialized for transferring nanoliter or smaller volume quantities of chemical concentrates, or microliter quantities of assay reagents, cells, media and other assay constituents. Applications of this invention include the quantitation and analysis of the expression of multiple genes in cells, measurement of multi-gene expression kinetics, analysis of activation or suppression of multiple signal transduction pathways, screening chemical compounds for modulatory effects on multi-gene expression or on signal transduction pathways or on other biochemical networks of cells, or other analytical biological or biochemical assays.

Automated laboratory for high-throughput biological assays and RNA interference

Sensor for levels of conductive liquids

Multiwell plate assembly for use in high throughput assays

Growing community of inventors

San Diego, CA, United States of America

Javier Humberto Flores