University of British Columbia

British Columbia Cancer Agency Branch

Brittish Columbia Cancer Agency Branch

Columbia University

Javier Garcia Fernandez

Raymond John Andersen

Marianne Dorothy Sadar

Nasrin R Mawji

Carmen Adriana Banuelos

Kunzhong Jian

Jun Wang

Yusuke Imamura

Jian Kunzhong

Amy (Hsing Chen) Tien

Marianne D Sadar

Hsing Chen Tien

Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, R, R, R, R, X, n, n, and nare as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Heterocyclic compounds for cancer imaging and treatment and methods for their use

Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, R, R, R, R, X, n, n, and nare as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided. 

This invention provides bisphenol derivatives having a structure of formula 1. Said compounds are modulators of the androgen receptor activity and are useful in the treatment of various diseases, including prostate cancer, breast cancer, ovarian cancer, endometrial cancer, acne, ovarian cysts, polycystic ovarian disease, age-related macular degeneration, precocious puberty, hirsutism and hair loss.

Bisphenol derivatives and their use as androgen receptor activity modulators

Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, R, R, X, X, Xand Xare as defined herein, and wherein the compound comprises at least one F, Cl, Br, I orI moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.

Halogenated compounds for cancer imaging and treatment and methods for their use

Compounds having a structure of Structure I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R, R, R, R, R, J, J, X, Z, nand nare as defined herein, and wherein at least one of R, Ror Ris an alkyl, alkenyl, aryl or aralkyl ester, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.

Ester derivatives of androgen receptor modulators and methods for their use

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Asturias, Spain

Javier Garcia Fernandez