Council of Scientific and Industrial Research

The University of Melbourne

Javed Naim Agrewala

David Charles Jackson

Weiguang Zeng

Ravinder Singh Jolly

Uthaman Gowthaman

Arvind Kumar Singla

Rakesh Mulraj Vohra

Naresh Sharma

Jolly Ravinder Singh

The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogenin this case. In the present invention, promiscuous peptides ofare conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. 

Synthetic immunogen useful for generating long lasting immunity and protection against pathogens

The present invention relates to an isolated bioactive molecule Caerulomycin A, derivatives and analogs thereof as effective immunosuppressive agents. The immunosuppressive property of the compound is targeted in particular against the lymphocytes, CD4T cells, CD8T cells and B cells and in the production of IL-4 and IFN-&#x3b3; and antibodies. The compound operates through a mechanism by downregulating the expression of activation marker CD28 and upregulating the immunosuppressive marker CTLA-4. Caerulomycin A has previously been isolated fromand found to have useful antifungal activity. Prior to the present invention however, this compound had not been determined to have immunomodulatory activity.

Use of bipyridine compound 'Caerulomycin A' derivatives and analogs thereof as immunosuppressive agents

The present invention relates to a process for the preparation of a vaccine against tuberculosis and other intracellular pathogens, this vaccine is targeted against intracellular pathogens, more particularly the pathogen and Salmonella in this case.

Process for the preparation of a vaccine for the treatment of tuberculosis and other intracellular infections diseases and the vaccine produced by the process

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Chandigarh, India

Javed Naim Agrewala