The United States of America, As Represented by the Secretary, Department of Health and Human Services

University System of Maryland

Javed Khan

Carsten Peterson

Paul S Meltzer

Markus Ringner

Tai Chi Cheuk

Markus Ringnér

Dimiter Stanchev Dimitrov

Zhongyu Zhu

Rimas J Orentas

Sivasubramanian Baskar

Jun Stephen Wei

Michael Sears Fuhrer

Braden T Greer

James G Taylor, Vi

Romel Del Rosario Gomez

Herman Pandana

Konrad Aschenbach

Jun Wei

Michael Fuhrer

Romel Del Gomez

Monoclonal antibodies selected from immunized mice, immunized rabbits and a human scFv library that specifically bind fibroblast growth factor receptor 4 (FGFR4) are described. Chimeric antigen receptors, antibody-drug conjugates, immunoconjugates, bispecific antibodies and immunoliposomes comprising the disclosed FGFR4-specific antibodies are also described. The antibody compositions can be used to diagnose or treat a FGFR4-positive cancer, such as rhabdomyosarcoma, lung cancer, liver cancer, breast cancer, pancreatic cancer or prostate cancer.

Monoclonal antibodies specific for fibroblast growth factor receptor 4 (FGFR4) and methods of their use

A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition.

Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states

A method of predicting the outcome of a patient with neuroblastoma that includes obtaining experimental data on gene selections. The gene selection functions to predict the outcome of a patient with neuroblastoma when the expression of that gene selection is compared to the identical selection from a non-neuroblastoma cell or a different type of neuroblastoma cell. The invention also includes a method of targeting at least one product of a gene that includes administration of a therapeutic agent. The invention also includes the use of a gene selection for predicting the outcome of patient with neuroblastoma.

Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastoma

A method of diagnosing a disease that includes obtaining experimental data on gene selections. The gene selection functions to characterize a cancer when the expression of that gene selection is compared to the identical selection from a noncancerous cell or a different type of cancer cell. The invention also includes a method of targeting at least one product of a gene that includes administration of a therapeutic agent. The invention also includes the use of a gene selection for diagnosing a cancer.

Sets of probes and primers for the diagnosis of select cancers

This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR4 variants, which are linked to increased risk of tumor metastasis. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.

Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors

A microarray apparatus is provided which contains at least one chip having source and drain electrodes positioned on an array of carbon nanotube transistors which allows for electronic detection of nucleic acid hybridizations, thereby affording both increased sensitivity and the capability of miniaturization.

Apparatus for microarray binding sensors having biological probe materials using carbon nanotube transistors

Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers

Growing community of inventors

Derwood, MD, United States of America

Javed Khan