Glaxo Group Limited

Smithkline Beecham Corporation

Other

Glaxosmithkline LLC

Mitsubishi Tanabe Pharma Corporation

University of Reading

Jason Witherington

David Matthew Wilson

Sanjeet Singh Sehmi

David Kenneth Dean

Mark James Bamford

Stephen Garland

John Liddle

Robert William Ward

Olivier Mirguet

Romain Luc Marie Gosmini

David Glynn Smith

David Haigh

James Bailey

Deidre Mary Bernadette Hickey

David Michael Hodgson

Daniel F Veber

Christopher Norbert Johnson

Emmanuel Hubert Demont

Thomas Daniel Heightman

Andrew Kenneth Takle

Dennis Lee

Richard Leonard Elliott

Ian David Wall

Krista B Goodman

David Nigel Hurst

Nigel Paul King

Jag Paul Heer

Andrew D Gribble

Mark A Hilfiker

Alessandra Gaiba

Haifeng Cui

Robert A Stavenger

John Skidmore

Robert W Marquis

Derek Anthony Rawlings

Ashley Edward Fenwick

Terence Aaron Panchal

Nicholas Bailey

Ian Christopher Richards

Jean-Louis Brayer

Romain Luc Gosmini

Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

Benzodiazepine bromodomain inhibitor

The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Oxadiazole derivatives active on sphingosine-1-phosphate (S1P)

The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Benzazepine derivatives for the treatment of neurological disorders

The present invention relates to benzazepine derivatives of formula (I) wherein: Rrepresents &#x2014;Ccycloalkyl optionally substituted by Calkyl; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

The present invention relates to novel pyridone derivatives capable of inhibiting &#x3b1;integrin mediated cell adhesion, processes for their preparation, compositions comprising them and their use in the treatment of diseases capable of being modulated by the inhibition of cell adhesion.

Compounds

The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, Rand Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors. Pharmaceutical compositions comprising the compounds methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

Piperazine derivatives useful for the treatment of gastrointestinal disorders

A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, wherein Xis a group selected from N or CRand Xis a group selected from O, S or NR; Xand Xwhich may be the same or different is a group selected from N or CR; Xis a group selected from O, S or NRand Xis N or CR; X, Xand Xmay be the same or different and selected from a group N or CR; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.

Imidazopyridine derivatives as kinase inhibitors

The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; Ris unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl, aralkyl wherein the aryl and the alkyl moieties may each independently be unsubstituted or substituted, aralkenyl wherein the aryl, and alkenyl moieties may each independently be unsubstituted or substituted, unsubstituted or substituted heterocyclyl, or heterocyclylalkyl wherein the heterocyclcyl and the alkyl moieties may each inedepently be unsubstituted or substituted; and Ris unsubstituted aryl or unsubstituted or substituted or substituted heteroaryl. Additionally the present invention inlcudes a process for preparing such a compound, a pharmaceutical composition containing such a compound, and the use of such a compound in medicine.

Pyrazolopyridines and pyrazolopyridazines as antidiabetics

The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; Ris unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl, aralkyl wherein the aryl and the alkyl moieties may each independently be unsubstituted or substituted, aralkenyl wherein the aryl, and alkenyl moieties may each independently be unsubstituted or substituted, unsubstituted or substituted heterocyclyl, or heterocyclylalkyl wherein the heterocyclyl and the alkyl moieties may each independently be unsubstituted or substituted; and Ris unsubstituted aryl or unsubstituted or substituted or substituted heteroaryl. Additionally the present invention includes a process for preparing such a compound, a pharmaceutical composition containing such a compound, and the use of such a compound in medicine.

The present invention relates to novel compounds, in particular to novel pyrazolopyridine derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds in medicine. 

Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors

The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy-or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.

Protease inhibitors

Rearrangement of epoxides

Growing community of inventors

Harlow, United Kingdom

Jason Witherington