Plexxikon Inc.

Jason Walters

Jack Lin

Marika Nespi

Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2: wherein Ris C(O)R; Ris alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R; and each Ris independently C-Calkyl, CN, C-Calkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

Synthesis of heterocyclic compounds

Forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid were prepared and characterized in the solid state:  Also provided are processes of manufacture and methods of using the forms of Compound I.

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Union City, CA, United States of America

Jason Walters