Zalicus Pharmaceuticals, Ltd.

Praxis Precision Medicines, Inc.

Taro Pharmaceuticals Inc.

Jason Tan

Hassan Pajouhesh

Yanbing Ding

Ramesh Kaul

Yuanxi Zhou

Nagasree Chakka

Yongbao Zhu

Lingyun Zhang

Mike Grimwood

Michael Edward Grimwood

Hossein Pajouhesh

Richard James Holland

Francesco Belardetti

Navjot Chahal

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1). 

N-piperidinyl acetamide derivatives as calcium channel blockers

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6). 

Bicyclic pyrimidine derivatives as calcium channel blockers

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Vancouver, Canada

Jason Tan