Genentech, Inc.

Jason R Zbieg

Jun Liang

Xiaojing Wang

Daniel Fred Ortwine

Sharada Shenvi Labadie

Birong Zhang

Nicholas Charles Ray

Simon Charles Goodacre

Paul Powell Beroza

Bing-Yan Zhu

Jun M Li

Lisa Marie Barton

Tao Wang

Vishal Verma

Ramsay Beveridge

Marie Anne Evangelista

Jiangpeng Liao

Bryan Ka Ip Chan

Samir Bouayad-Gervais

Russell Tyler Smith

Anwesha Dey

Monique Bodil Van Niel

Wendy Lee

Christopher Hurley

Georgette M Castanedo

James John Crawford

Benjamin Fauber

Andrew Peter Cridland

Emanuela Gancia

Stuart Ward

Robin Larouche-Gauthier

Alberto Gobbi

Olivier Rene

Zhiguo Liu

Malcolm Huestis

Sarah Bronner

Jonathan Killen

John Wai

Patrick Cyr

Paul Winship

Liang Zhao

Tommy Lai

Fabio Broccatelli

Man Un Ung

Araz Jakalian

Michael John Lambrecht

Curtis Colwell

Melissa Leblanc

Arun Yadav

Maia Vinogradova

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Therapeutic compounds and methods of use

This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure:

Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof

A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

Lactams as CBL-B inhibitors selective over C-CBL

Pyrazolo compounds and methods of use thereof

Compounds of formula I: or pharmaceutical salts thereof,wherein m, n, p, q A, B, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Pyridazine derivatives as RORc modulators

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure:  and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Described herein are heteroaryl compounds with estrogen receptor modulation activity or function having the Formula I, II, and III structures: and

Heteroaryl estrogen receptor modulators and uses thereof

Described herein are tetrahydronaphthalene compounds with estrogen receptor modulation activity or function having the Formula I structure: 

Tetrahydronaphthalene estrogen receptor modulators and uses thereof

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Described herein are tetrahydroisoquinoline compounds with estrogen receptor modulation activity or function having the Formula I structure: 

Tetrahydroisoquinoline estrogen receptor modulators and uses thereof

Growing community of inventors

Montara, CA, United States of America

Jason R Zbieg