Yale University

Lifecell Corporation

Jason Park

Richard A Flavell

Tarek M Fahmy

Eric D Stern

Alyssa Siefert

Stephen H Wrzesinski

E Skott Greenhalgh

Aaron M Barere

Jerome Connor

Robert A Kiefer

Christopher T Wagner

A 'nanolipogel' is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution.

Nanolipogel vehicles for controlled delivery of different pharmaceutical agents

The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.

Reinforced biologic material

Growing community of inventors

New York, NY, United States of America

Jason Park