Seattle Biomedical Research Institute

US Government As Represented by the Secretary of the Army

Philadelphia Health and Education Corporation

The United States of America As Represented by the Army

Jason P Wendler

Patrick Emmet Duffy

Andrew V Oleinikov

Michal Fried

Susan Francis

Theonest K Mutabingwa

Stefan H I Kappe

Igor Bacik

Lawrence W Bergman

Vladislav A Malkov

Urszula Krzych

Donald G Heppner

Alice Tarun

The invention provides isolated liver stagepolypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stagepolypeptides of the invention, compositions comprising one or more liver stagepolypeptides of the invention, methods for inducing an immune response against the liver stagepolypeptides, and methods for treating and diagnosing liver stage malaria.

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The invention provides isolated placentalpolypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the placentalpolypeptides of the invention, compositions comprising one or more placentalpolypeptides of the invention, methods for inducing an immune response against the placentalpolypeptides, and methods for treating and diagnosing placental malaria.

Malaria vaccines

Growing community of inventors

Lincoln, NE, United States of America

Jason P Wendler