Northwestern University

Other

University of Illinois

Jason Ng

Rishi R Arora

Alan Kadish

Timothy J Carroll

Rishi K Arora

Jeffrey J Goldberger

David Gordon

Roger Olds

Marquis Burnett

Paras Parikh

Daniel C Lee

Rlshi Arora

The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.

Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity

Described here are systems and methods for producing high-resolution three-dimensional ('3D') relaxation parameter maps by calibrating high-resolution 3D magnetic resonance images. As one example, high-resolution longitudinal relaxation time ('T1') maps can be generated based on images acquired using a T1-weighted pulse sequence, and as another example high-resolution transverse relaxation time (&#x201c;T2&#x201d;) maps can be generated based on images acquired using a T2-weighted pulse sequence. The high-resolution images can be calibrated, for example, using a lower resolution single slice relaxation parameter map. The methods described here utilize high-resolution 3D scans and low-resolution relaxation parameter maps that are commonly available on MRI systems. The calibration is a post-processing step used to create the high-resolution 3D relaxation parameter maps from these two types of scans.

System and method for producing high-resolution magnetic relaxation parameter maps

At least one location of interest for perpetuation or persistence of arrhythmia or atrial fibrillation is identified by determining a repeatability of electrogram morphologies from electrical recordings within at least one atrium.

System and method for determining electrogram morphology recurrence patterns and rates during atrial fibrillation

A method of targeting fibrosis or autonomic nerve tissue for ablation in a subject is provided. The method includes performing at least one EGM analysis of a plurality of recorded atrial EGMs for a tissue in a region suspected of having fibrosis or autonomic nerve tissue. With regard to targeting fibrosis for ablation, the method includes determining one or more correlations of at least one AF EGM characteristic to a region having fibrosis from the plurality of recorded atrial EGMs for the tissue and determining whether the tissue contains dense fibrosis that would preclude effective ablation of the analysis region of the tissue. With regard to targeting autonomic nerve for ablation, the method includes determining whether one or more significant changes in EGM characteristics with autonomic blockade exist that would indicate the need to perform ablation of the analysis region of the tissue.

Using intracardiac electrograms to predict location of fibrosis and autonomic nerves in the heart

A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. In another step, a determination is made as to whether a mean of the plurality of cycle lengths meets at least one criteria. The method may be used to iteratively adjust a detection threshold level for detecting atrial fibrillation based on the cardiac electrogram.

Cycle length iteration for the detection of atrial activations from electrogram recordings of atrial fibrillation

An illumination system has a housing that rotates with a vehicle wheel, and the housing has a cavity with lighting and controls within the cavity. Light from the cavity is directed onto a vehicle wheel, and the light flashes in relationship to the rotation speed of the wheel which makes the wheel appear to be stationary or slowly rotate in a backward or forward direction.

Growing community of inventors

Evanston, IL, United States of America

Jason Ng