General Electric Company

Bl Technologies, Inc.

Global Life Sciences Solutions Operations UK Ltd

Jason Michael Nichols

James Manio Silva

Christopher Michael Puleo

Paul Michael Smigelski, Jr

Louisa Ruth Carr

John Richard Nelson

Naresh Sundaram Iyer

David Roger Moore

Matthew Jeremiah Misner

Erik Leeming Kvam

Hongyi Zhou

Ralf Lenigk

Brian Christopher Bales

Erin Jean Finehout

Gregory Andrew Grossmann

Frank John Mondello

Craig Patrick Galligan

Cathryn Ellen Olsen

Bing Li

William Christopher Alberts

Nurali Virani

Johan Michael Reimann

Jason Louis Davis

Xuefeng Wang

Danielle Kalitan

John Nelson

Paul Michael Smigelski

A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).

Porous membranes with a polymer grafting, methods and uses thereof

According to some embodiments, a system, method and non-transitory computer-readable medium are provided comprising a Hypothesis Generation Engine (HGE) to receive one or more property target values for a material; a memory for storing program instructions; an HGE processor, coupled to the memory, and in communication with the HGE, and operative to execute program instructions to: receive the one or more property target values for the material; analyze the one or more property target values as compared to one or more known values in a knowledge base; generate, based on the analysis, an initial set of hypothetical structures, wherein each hypothetical structure includes at least one property target value; execute a likelihood model for each candidate material to generate a likelihood probability for each hypothetical structure, wherein the likelihood probability is a measure of the likelihood that the hypothetical structure will have the target property value; convert each hypothetical structure into a natural language representation; execute an abduction kernel on the natural language representation with the at least one likelihood probability, to output at least one proposed structure that satisfies a likelihood threshold for having the property target value; and receive the output of the executed abduction kernel at a testing module to determine whether the output satisfies the property target values. Numerous other aspects are provided.

Autonomous reasoning and experimentation agent for molecular discovery

Provided herein are copolymers and copolymer compositions that are both hydrophilic and oleophobic. The copolymers include structural units derived from a fluoroalkyl monomer and a zwitterionic monomer. It further relates to membranes formed by coating a porous substrate with the copolymeric compositions. The copolymeric coating imparts hydrophilicity and oleophobicity/oil-tolerance to the membranes. The uses of such membranes as microfiltration membrane or ultrafiltration membrane are also provided.

Hydrophilic-oleophobic copolymer composition and uses thereof

The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.

Detection of nucleic acid amplification in a porous substrate

A system is provided for separating particulates dispersed within a base fluid wherein at least one of the particulates and the base fluid is an organic liquid. The system relies on a microfluidic separation device comprising a microchannel in fluid communication across a microporous body with a collection chamber. Particulates and a portion of the base fluid traverse the microporous body under the influence of an external force field and are collected in the collection chamber. A first fluid flow having a first flow rate through the microchannel together with the microporous body operationally generate a second fluid flow within the collection chamber as base fluid and particulates traverse the microporous body and enter the collection chamber, and as base fluid re-traverses the microporous body and re-enters the microchannel, the second fluid flow having a flow rate which is a fraction of the first flow rate.

Systems for separation of particulates and associated methods and devices

A porous membrane patterning technique is provided. In one embodiment, a porous membrane may be patterned via printing on the porous membrane with a solvent such that the porous membrane collapses where the solvent is applied. In another embodiment, a patterned porous membrane may be formed by casting a solution including at least components of the porous membrane into voids of a casting plate or stencil, removing the casting plate, and letting the remaining components go through a phase inversion process to form porous membrane regions.

Porous membrane patterning technique

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Schenectady, NY, United States of America

Jason Michael Nichols