International Flavors & Fragrances Inc.

Chromocell Corporation

Jason Michael Montez

Stephen Gravina

Mark Lawrence Dewis

Kambiz Shekdar

Dennis J Sawchuk

Hailin Wang

Vijyeta Kapur

Carrie Ann Maxwell

Methods of isolating cells or generating cell lines comprising the step of exposing the cells to signaling probes that produce a signal upon hybridization to a target sequence, as well as methods of quantifying the level of expression of an RNA of interest, methods for identifying genetic recombinational events in living cells and methods of generating a transgenic animal using the isolated cells. Methods for isolating a plurality of cells encoding a plurality of different RNAs associated with a same nucleic acid tag sequence, comprising the step of exposing the cells to a same signaling probe that produces a detectable signal upon hybridization to the same nucleic acid tag sequence, are also provided. Signaling probes and protease probes that form stem-loop structures, three-arm junction structures, and dumbbell structures may be used in the above methods.

Methods and materials using signaling probes

The present invention is an isolated nucleic acid molecule encoding CD36, G, and G protein-coupled receptor 84 (GPR84) proteins as well as vectors and recombinant host cells which co-express CD36, G, and GPR84 proteins for use in identifying modulators of GPR84 activity.

Nucleic acid molecules encoding GPR84

The Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) protein has been identified as an ester cooler receptor and therefore is useful in screening assays for identifying ester coolers, in particular ester coolers with a relative cooling strength which exceeds (&#x2212;)&#x2212;menthol.

Method for identifying ester coolers

Growing community of inventors

Rumson, NJ, United States of America

Jason Michael Montez