Dexcom, Inc.

Quidel Corporation

Ortho-clinical Diagnostics, Inc

Jason McClure

Mark Allan Tapsak

Mark C Shults

Rathbun K Rhodes

Robert Reed

Robert Weiller

Peter Yan-Guo Ren

Irene Sinn Blandy

Samantha Chang

Christian Bobritchi

Kevin S Richardson

Jason J Sun

Irene Sinn

Hyunjin Kim

Irene Sinn-Blandy

Stephanie Pinedo

Cristian Alberto

Stewart Hoelscher

Methods, compositions and kits for detecting Group Ain a biological sample are described. More particularly, the present disclosure provides an immunoassay in which the specificity of detection of Group Ais enhanced by addition of N-acetyl-D-glucosamine. These methods, compositions and kits are useful in convenient, reliable and early diagnosis of streptococcal infection in a human subject.

N-acetyl-D-glucosamine for enhanced specificity of strep a immunoassay

A substrate structured to define thereon a fluid flow channel and/or a fluid control feature is described. The substrate may additionally comprise a capture zone and/or a test zone, for use as a test strip for determining presence or absence of an analyte of interest, such as an infectious agent or a biomarker. Reagents are deposited in the capture zone and/or test zone as an array of drops.

Substrate with channels for controlled fluid flow

A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone. Test lines in each fluid flow path capture a mobile detectable species as an indicator of presence or absence of the infectious agent. The device also comprises a reference line positioned in the one of the fluid flow paths. The bidirectional fluid flow paths emanate from a common sample zone and provide an efficient approach to detection and differentiate two species as indicators of the same infectious agent or as indicators of two different infectious agents.

Immunoassay test device with two fluid flow paths for detection and differentiation of two or more analytes

An enzymatic extraction agent, as well as methods, compositions and kits for detecting Group Ain a biological sample, which involve the enzymatic agent, are described.

Extraction reagent for use in an assay for detection of group A

Embodiments of the present disclosure relate to chimeric antibodies which specifically bind todecorin-binding protein A (DbpA) antigens and compositions or kits comprising such antibodies. The disclosure further relates to use of such antibodies in the detection ofsp. in samples, e.g., biological samples such as human blood and/or tissues of deer, ticks and other carriers of. Embodiments of the disclosure further relate to diagnosis and/or therapy of Lyme disease using the chimeric antibodies and/or compositions containing the chimeric antibodies.

DbpA antibodies and uses thereof

N-acetyl-D-glucosamine for enhanced specificity of Strep A immunoassay

The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400&#xd7; magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

Techniques to improve polyurethane membranes for implantable glucose sensors

Growing community of inventors

San Diego, CA, United States of America

Jason McClure