Vanderbilt University

F. Hoffmann-la Roche Ag

Jason Manka

Craig William Lindsley

P Jeffrey Conn

David Bernard Smith

Shaun R Stauffer

Ya Zhou

Gregor James MacDonald

José Manuel Bartolomé-Nebreda

Susana Conde-Ceide

Carrie K Jones

David Garrett Loughhead

Daisy Joe Du Bois

Jon Jacobs

Gregor McDonald

José Manuel Bartolome-Nebreda

Eric S Dawson

Hans Maag

In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators

In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Naphthyridinone analogs as mGluR5 positive allosteric modulators

In one aspect, the invention relates to dihydronaphthyridinyl(organo)methanone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Dihydronaphthyridinyl(organo)methanone analogs as positive allosteric mGluR5 modulators

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Nashville, TN, United States of America

Jason Manka