Pharmacia & Upjohn Company

Pfizer Corporation

Jason K Myers

David W Piotrowski

Vincent E Groppi, Jr

Eric Jon Jacobsen

Bruce Nelsen Rogers

Alice L Bodnar

Daniel Patrick Walker

Jeffrey W Corbett

Brad A Acker

Donn G Wishka

Steven Charles Reitz

The invention provides compounds of Formula I:wherein Azabicyclo isW is a six-membered heterocyclic ring system having 1&#x2013;2 nitrogen atoms or a 10-membered bicyclic-six-six-fused-ring system having up to two nitrogen atoms within either or both rings, provided that no nitrogen is at a bridge of the bicyclic-six-six-fused-ring system, and further having 1&#x2013;2 substitutents independently selected from R. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat diseases or conditions in which &#x3b1;7 is known to be involved.

Azabicyclic compounds for the treatment of disease

The invention provides compounds of Formula I:Azabicyclo-N(R)&#x2014;C(&#x2550;X)&#x2014;W&#x2003;&#x2003;Formula IThese compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which &#x3b1;7 is known to be involved.

Azabicyclic-substituted-heteroaryl compounds for the treatment of disease

The invention provides compounds of Formula I:

Substituted azabicyclic moieties for the treatment of disease

The invention provides compounds of Formula I:These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals to treat diseases or conditions in which &#x3b1;7 is known to be involved.

Substituted-aryl compounds for treatment of disease

Quinuclidine-substituted heteroaryl moieties for treatment of disease

Substituted-heteroaryl-7-aza&lsqb;2.2.1&rsqb;bicycloheptanes for the treatment of disease

Quinuclidine-substituted aryl compounds for treatment of disease

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Kalamazoo, MI, United States of America

Jason K Myers