Pfizer Corporation

Jason K Dutra

Michael Anthony Letavic

Hengmiao Cheng

Brian S Bronk

Peter Bertinato

Subas Man Sakya

Robert J Rafka

Hengmaio Cheng

Carl B Ziegler, Jr

The present invention relates to compounds of the formula:wherein R, R, R, R, R, R, R, R, A, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

Pyrazole ether derivatives as anti-inflammatory/analgesic agents

The invention relates to compounds of the formula I ##STR1## and to pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, Q, X, Y and Z are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I, methods of using said compounds of formula I in the treatment of infections, and methods of preparing said compounds of formula I.

Macrolide derivatives

This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial agents that may be used to treat various bacterial infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.

C11 carbamates of macrolide antibacterials

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Salem, CT, United States of America

Jason K Dutra