Emerson Electric Company

Arqule, Inc.

Cubist Pharmaceuticals, Incorporated

Avedro, Inc.

Other

Merck + Co., Inc.

Jason J Hill

Mark Anthony Ashwell

Nivedita Namdev

Mark J Tomasiak

Dennis D Keith

John F Finn

Manish Tandon

Yanbin Liu

Rocio Palma

Douglas C Schultz

Syed M Ali

Michael Morytko

David Vensel

Robert B Nicewonger

Chris Brassard

Anton Filikov

Jean-Marc Lapierre

Magdi Moussa

Matthew A Williams

Chiang Jia Li

Jared Silverman

Akihisa Matsuda

Tsvetelina Ivanova Lazarova

Jianqiang Wang

Shin Iimura

Neil Westlund

Steffi Koerner

Alan D Watson

Neru Munshi

Ian Parr

Jim Siedlecki

Dale Christensen

Yan Zhang

Joseph L Tevaarwerk

Audra Dalton

Takeshi Isoyama

Xian Yang Yu

Mark A Ashwell

Kenichi Yoshida

Desmond Christopher Adler

Sherman Tim Waddell

Milton L Hammond

Shane Glasgow

Milana M Maletic

Takahiro Kitamura

Robert R Hollis

Eugene W Kelleher

Yuko Yamamoto

Gina M Santorelli

Aaron H Leeman

Rui-Yang Yang

Mark S Amalfitano

Takanori Yamazaki

John Wolford

Woj Wrona

Mark S Evertowski

Xiang Yang Yu

Kiyoshi Hoshino

Alex J Wall

John L Theising

Jeffrey Scott Sherman

David Usher

Christopher Burch

Stephen J Burton

Hui Wu

Jeremy Sanders

Donald E Morgan

Mikhail Smirnov

Vikas Mahadev Jadhav

Thomas E Fogarty

Kiyo Hoshino

Sudharshan Eathiraj

Paul L Gallant

David Martele Goggans

Jeffrey Link

Liam McGreal

Christopher Lutz

Philip A Wendler

Amit Mukherjee

Behrouz Tavakol

Thomas L McCue

Alex Yildizyan

Jie Zhang

Zhongguo Wang

Stephen Nadler

Michael Topham

Dilip Shivnarayan Akhade

Nicholas James Cooley

Katherine Hagerty

Robert Nicewonger

Mark Antony Ashwell

Magdi M Moussa

Nivedita D Namdev

This disclosure features bis(diazirine) derivatives of the formulae (I) (1-a) or (1-b) that generate cross-linking in the cornea in response to exposure to an electromagnetic irradiation (e.g. UV-light). The compounds are useful, e.g. for treating a subject (e.g. a human) having a disease, disorder or condition in which abnormal shaping of the cornea (e.g. thinning of the cornea, e.g. bilateral thinning of the cornea, e.g. bilateral thinning of the central, paracentral, or peripheral cornea, or steepening (e.g., bulging) of the cornea) contributes to the pathology and/or symptoms, and/or progression of the disease, disorder or condition. Examples of such diseases, disorders or conditions include: (i) corneal ectatic disorders; (ii) vision conditions; and (iii) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular examples of such diseases, disorders or conditions include keratoconus, keratoglobus, pellucid marginal degeneration, corneal ectasia (e.g. postoperative ectasia, e.g. post-LASIK ectasia), Terrien's marginal degeneration, myopia, hyperopia, astigmatism, irregular astigmatism and presbyopia. In some embodiments, the claimed methods can be performed in the absence of added or supplemental oxygen levels, which can be advantageous in some applications. Preferred exemplary compounds are e.g. bis(diazirine) amino acid derivatives, such as e.g. example:

Bis(diazirine) derivatives as photo-crosslinker for treating corneal ectatic disorders

Vacuum conduit pipe adapter

A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.

Photoactivation systems and methods for corneal cross-linking treatments

An apparatus and method for managing power supplied to a portable electrical device includes an electrical connector configured to engage a complementary electrical connector of the respective battery. The portable battery-powered device also includes a selector switch configured to couple the electrical connectors of the plurality of power receptacles in at least one of a series configuration, a parallel configuration, and a combination of series and parallel configuration. The portable battery-powered device further includes an electrical load device including one or more electrical leads coupled to the selector switch. The selector switch is selectable during operation of the portable battery-powered device to provide power to the electrical device from a plurality of battery packs coupled in the at least one of a series configuration, a parallel configuration, and a combination of series and parallel configuration.

Systems and methods for selectable battery configuration in a portable device

A vacuum cleaner includes a housing, a debris chamber defined within the housing, a filter disposed within the debris chamber, a motor assembly including a motor and an impeller connected to the housing and operable to generate airflow through the debris chamber and filter, a voltage sensor positioned to detect an input voltage applied to the motor, a temperature sensor positioned to detect a temperature associated with the motor and a controller communicatively coupled to the voltage sensor, temperature sensor, and motor. The controller includes a processor and memory having instructions that program the processor to determine a threshold temperature based at least in part on the input voltage detected by the voltage sensor, compare the temperature associated with the motor to the threshold temperature, and output a warning that the filter is full of debris when the temperature associated with the motor exceeds the threshold temperature.

Temperature based vacuum cleaner full bag indication

A vacuum cleaner assembly designed for use in a vehicle having a passenger compartment such as those with at least one row of seats and a cargo area. The vacuum cleaner assembly preferably includes a power head, a collection drum or other container, and a hose. The powerhead of the present invention is powered by the vehicle's electrical system and is preferably mounted between exterior body panels and interior compartment panels of the vehicle. For example, the power head may be mounted between the exterior body panels and the interior compartment panels adjacent to, but not in the cargo area.

Transportation vacuum assembly

A vacuum cleaner tube assembly includes an outer tube defining a vacuum passage extending from a first end to a second end and an inner tube disposed at least partially within the vacuum passage and connected to the outer tube for telescopic adjustment. The inner tube includes a first end and a second end distal from the first end. The vacuum tube assembly further includes an adjustment clamp connected to the second end of the outer tube. The adjustment clamp includes a clamp body with an inner diameter connected to the second end of the outer tube. The adjustment clamp also includes a lever connected to the clamp body and moveable between a first, latched position and a second, unlatched position to permit selective adjustment of the inner diameter of the clamp body and selective clamping between the clamp body and the inner tube.

Adjustable vacuum tube clamp assembly and vacuum cleaners including same

A system is disclosed comprising a DC power supply for supplying DC power to a device having a universal electric motor configured to operate on AC power. The system is configured to have a first authorization component associated with the device and second authorization component associated with the DC power supply so that DC power is supplied to device, or is continued to be supplied to the device, only when the first and second authorization components operatively engage.

Smart DC power supply for AC equipment

A vacuum accessory tool that includes a nozzle body having a first end and a second, spaced apart end and at least one light emitting element that emits light that will illuminate a surface to be cleaned by the accessory tool is described. The light emitting element is protected by a protective housing that protects the element when the tool is inserted into areas during cleaning, yet still allows the light to illuminate surfaces during operation.

Vacuum nozzle with integrated light

A vacuum module for installation in a console located in a passenger compartment of a vehicle includes a housing defining a receptacle, a debris container received within the receptacle and removably connected to the housing by a latch, and a motor connected to the housing and operable to generate air flow through the debris container from an inlet of the vacuum module to an outlet of the vacuum module. The housing includes a mounting flange that engages a mounting surface of the console to secure the vacuum module within a storage cavity of the console. The debris container includes a filter assembly removably connected to a base of the debris container. The vacuum module defines a single unit that is removable from the console.

Vehicle vacuum module and methods of installing same

A vacuum appliance comprising a drum and a vacuum head. The drum may include a base and a cylinder sealed to the base. The vacuum head may include a lid and a blower. The lid preferably includes a portion that is detachably mounted to an open upper end of the drum. The blower may be mounted to, atop, or within the lid. In any case, the blower induces a vacuum within the drum and moves through the vacuum. The base or the cylinder may include a drain to drain fluid and debris contained within the drum. The lid may include a lower portion sealed to and defining the open upper end of the drum. The cylinder or the lid may include an air inlet through which the blower draws air and entrained debris.

Vacuum having a metal drum and a polymer base

The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention and also administering a effective amount of a chemotherapeutic agent.

Compositions and methods for treatment of cancer

Growing community of inventors

Manchester, MO, United States of America

Jason J Hill