Johns Hopkins University

Jason J Benkoski

Rengaswamy Srinivasan

George L Coles

Chao-Wei Hwang

Morgana M Trexler

Christopher M Hoffman, Jr

Keith S Caruso

Hala J Tomey

Robert C Matteson, Iii

Xiomara Calderon-Colon

Jon R Resar

Paul J Biermann

Steven M Griffiths

Konstantinos Gerasopoulos

Marcia W Patchan

Jeffrey P Maranchi

Jennifer L Sample

Luis Garza

Julia B Patrone

Jennifer L Breidenich

Gordon Tomaselli

Robert G Weiss

Gary Gerstenblith

Peter V Johnston

Joshua T Wolfe

Lisa A Kelly

Steven P Schulman

Amanda Nelson

Jeffrey A Brinker

Jon R Rosar

Melanie L Morris

Huong Le

James C Crookston

Mellisa L Theodore

Sewon Kang

Coating compositions include a binder that has a first polymeric material that does not undergo ultraviolet (UV) degradation and/or does not absorb UV radiation/light. The coating compositions may further include at least a first UV-reflective pigment dispersed throughout the binder. The coating compositions may be provided in a cured form as a solid coating layer that may overly at least a portion of a substrate.

Low solar absorptance coatings

Articles and insulating systems include a wicking layer, an incompressible insulation layer, and a water scavenging system comprising a superhydrophobic layer in operative communication with one or more water collecting components.

Incompressible moisture-scavenging article

A coating system may be configured to be applied to an aluminum-magnesium substrate of an object. The coating system may include a primer configured to reduce the corrosion rate of the aluminum-magnesium substrate and a topcoat configured to resist water and improve solar reflectance of the coating system. The primer may include a silicate and a first additive configured to increase corrosion resistance of the coating system The topcoat may include a siloxane and a second additive configured to reduce solar absorptance of the coating system.

Coating system for aluminum-magnesium alloys

A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

Methods for promoting healing of tissue

A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents.

Topical compositions and methods of detection and treatment

Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.

Method of manufacturing an implantable pressure-actuated drug delivery system

A metallic microcapsule containing a polymeric microcapsule having one or more polymeric precursors encapsulated therein; and a metallic shell enclosing a volume containing the polymeric microcapsule is disclosed. Also disclosed is a self-healing coating composition comprising (a) a film-forming binder; and (b) metallic microcapsules, the metallic microcapsules being the same or different and containing a polymeric microcapsule containing one or more polymeric precursors encapsulated therein; and a metallic shell enclosing a volume containing the polymeric microcapsule.

Self-healing coatings

Methods of manufacture and use of implantable pressure-actuated drug delivery systems

Implantable pressure-actuated drug delivery systems and methods of manufacture and use

Growing community of inventors

Catonsville, MD, United States of America

Jason J Benkoski