Psma Development Company, LLC

Amgen Fremont Inc.

Jason Gardner

William C Olson

Paul J Maddon

Dangshe Ma

Norbert Schuelke

Gerald P Donovan

Larry L Green

Jaspal Singh Kang

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

PSMA antibodies and uses thereof

The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of using the antibodies or antigen-binding fragments thereof for cancer diagnosis and treatment. The invention also includes oligomeric forms of PSMA proteins, compositions comprising the multimers, and antibodies that selectively bind to the multimers.

Compositions of PSMA antibodies

PSMA antibodies and protein multimers

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Merseyside, United Kingdom

Jason Gardner