Massachusetts Institute of Technology

Kibur Medical, Inc.

The General Hospital Corporation

Boston University

Whitehead Institute

Jason Fuller

Robert I Tepper

Robert Samuel Langer

Gerald R Fink

Ifat Rubin-Bejerano

Oliver Jonas

Claudia Abeijon

John Santini

J Christopher Flaherty

Jeffrey S Ross

Daniel S Kohane

Robert Langer

Jessica L Duda

Craig Muir

Danial S Kohane

Russell Hirsch

Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure. The microwells contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility (such as WiFi) to provide for in situ retrieval of information and modification of device release properties. In the most preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.

Implantable devices and methods for the evaluation of active agents

Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility to provide for in situ retrieval of information and modification of device release properties. In a preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.

Implantable devices and methods for evaluation of active agents

Described here are devices, systems, and kits for delivering substances to tissues. The devices generally include one or more chambers () and a reservoir () within each chamber. The reservoir may locally deliver a microdose amount of a substance to a target tissue. In some variations, a microdose amount is used in early human studies, e.g., before a phase I clinical trial, to evaluate the effect of the substance on a target tissue, or to obtain pharmacokinetic or metabolic data. In other variations, a microdose amount is used to locally treat a medical condition. In yet other variations, a microdose amount is used to locally deliver a contrast agent for a structural or functional imaging procedure. Methods for delivering and retrieving the devices from the target tissue are also described.

Device and method for drug evaluation and local treatment

This invention is directed to &#x3b2;-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The &#x3b2;-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.

Immunomodulating compositions and methods of use thereof

Immunomodulating compositions and methods of use

Growing community of inventors

Boston, MA, United States of America

Jason Fuller