N2 Biomedical LLC

Jason E Burns

Eric Tobin

Nader Montazemezam Kalkhoran

Techniques and devices including a biocompatible antibacterial film are provided. An example method for depositing a biocompatible antibacterial film using physical vapor deposition (PVD) includes providing a substrate in a PVD processing chamber, forming a deposited film by co-depositing a first material and a second material onto the substrate from a vapor plume, wherein at least the first material is biocompatible and at least the second material is antibacterial, and nano-texturing the deposited film to produce nano-scale surface asperities that provide at least one of inhibition of bacterial growth, promotion of osseointegration, promotion of epithelial attachment, or promotion of endothelial attachment.

Nano-textured biocompatible antibacterial film

Techniques for creating a mesoporous surface for enhanced bone integration are provided. An example of a method for generating a mesoporous surface on a substrate includes depositing a layer of titanium on an area of the substrate to generate a nano-textured surface, and anodizing the layer of titanium on the area of the substrate to generate the mesoporous surface. The method may also include incorporating pharmaceutical, biological, or molecular additives into the mesoporous surface intended to further enhance performance of the substrate via enhanced osseoconduction, osseoinduction, or antimicrobial/anti-infective properties.

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Cambridge, MA, United States of America

Jason E Burns