Flodesign Sonics, Inc.

Flodesign Wind Turbine Corporation

Fiodesign Sonics, Inc.

Jason Dionne

Bart Lipkens

Walter M Presz, Jr

Thomas J Kennedy, Iii

Brian Dutra

Louis Masi

Ari Mercado

Stanley J Kowalski, Iii

Edward Rietman

Arthur Martin

Goutam Ghoshal

Kedar C Chitale

Benjamin Ross-Johnsrud

Dane Mealey

Rudolf Gilmanshin

Jason Barnes

Jeff King

Eric Mitchell

Joey Carmichael

Michael J Werle

Robert H Dold

William Scott Keeley

Brian McCarthy

Thomas Joseph Kennedy

Rui Tostoes

David Sokolowski

Chris Leidel

Jason Gawencki

Timothy Hickey

John Rozembersky

John Urbanowicz

Bart Lipkiens

Anthony B Masi

Brian T Kennedy

Fyodor Grechka

Walter Presz

Brian Mccarthy

Iii Thomas J Kennedy

Stanley Kowalski Iii

Thomas Kennedy Iii

Edward A Rietman

Jr Walter Presz

Iii Stanley Kowalski

A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

Cell therapy processes utilizing acoustophoresis

Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.

Concentration and washing of particles with acoustics

Therapeutic cell washing, concentration, and separation utilizing acoustophoresis

Methods and systems for separating material from a host fluid use an acoustophoresis device. These methods and systems can deflect material (e.g., a second fluid, cells, beads or other particles, exosomes, viruses, oil droplets) in host fluid streams at high flow rates.

Separation using angled acoustic waves

An apparatus for separating particles from a fluid stream includes a flow chamber that has at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber. The transducer includes a piezoelectric array with at least two piezoelectric elements. The piezoelectric array includes a piezoelectric material to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer.

Acoustophoretic device with piezoelectric transducer array

A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

Acoustophoretic separation technology using multi-dimensional standing waves

A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.

Bioreactor using acoustic standing waves

Provided herein are systems and methods for separation of particulate from water using ultrasonically generated acoustic standing waves.

Ultrasound and acoustophoresis for water purification

An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.

Separation of multi-component fluid through ultrasonic acoustophoresis

Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as T cells, are separated from a host fluid for utilization in allergenic or autologous cell therapies. The disclosed devices and methods are capable of concentrating biological cells to at least 100 times their original cell concentration. The disclosed methods and devices are further capable of decreasing an original feed volume to a final concentrated volume that is less than one percent of the original feed volume.

System for generating high concentration factors for low cell density suspensions

A flow chamber is provided through which is flowed a mixture of a fluid and a particulate. The flow chamber comprises at least one multi-phase water inlet through which multi-phase water enters the flow chamber, a water outlet through which water exits the flow chamber, a solids outlet through which particles having a density at or above a pre-defined threshold exit the flow chamber, and a low density outlet through which particles having a density below the pre-defined threshold exit the flow chamber. Also provided are one or more ultrasonic transducers and one or more reflectors corresponding to each transducer to acoustically filter the fluid and cause particles/fluid to be selectively diverted to one of the outlets. Related apparatus, systems, techniques and articles are also described.

High-volume fast separation of multi-phase components in fluid suspensions

Acoustophoretic multi-component separation technology platform

Growing community of inventors

Simsbury, CT, United States of America

Jason Dionne