Tune Therapeutics, Inc.

Jason Dean

Joshua B Black

Veronica Gough

Kendra Congdon

Brian Cosgrove

Britta Jones

Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.

Compositions, systems, and methods for regulation of Hepatitis B virus through targeted gene repression

Compositions, systems, and methods for regulation of Hepatitis b virus through targeted gene repression

Compositions, systems, and methods for regulation of hepatitis B virus through targeted gene repression

Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression

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Seattle, WA, United States of America

Jason Dean