Array Biopharma Inc.

Genentech, Inc.

Jason De Meese

Jeongbeob Seo

Hongqi Tian

James F Blake

Steven Armen Boyd

John Joseph Gaudino

Wendy B Young

Allison L Marlow

Allen A Thomas

Alexandre Joseph Buckmelter

Li Ren

David A Moreno

Ellen Ruth Laird

Bainian Feng

Frederick Cohen

Brad Newhouse

Kin Chiu Fong

Simon Mathieu

Janet Gunzner

Joachim Rudolph

Jonas Grina

Zhaoyang Wen

Steven Mark Wenglowsky

Kateri Ahrendt

Joshua D Hansen

Kim Malesky

Paul Lunghofer

Tomas Kaplan

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. 

Pyrazole [3, 4-B] pyridine Raf inhibitors

Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. 

Heterobicyclic thiophene compounds and methods of use

Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. 

Heterobicyclic pyrazole compounds and methods of use

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Firestone, CO, United States of America

Jason De Meese