Therapeuticsmd, Inc.

Jason D Legassie

Peter H R Persicaner

Thorsteinn Thorsteinsson

Annette M Shadiack

Frederick D Sancilio

Philip B Inskeep

Julia M Amadio

Richard Winneker

Ajay Ghanta

This disclosure provides a novel pharmaceutical composition for delivering steroid hormones to a patient in need thereof.

Steroid hormone pharmaceutical composition

This disclosure provides a novel pharmaceutical composition capable of forming micelles upon exposure to the gastric environment. The pharmaceutical composition is suitable for delivering steroid hormones, and progesterone in particular, to a subject in need thereof.

Steroid hormone compositions in medium chain oils

This disclosure relates to transdermal pharmaceutical compositions containing progesterone in combination with one or more solubilizing agents and penetration enhancers, wherein the pharmaceutical compositions are formulated as creams for topical administration. In some embodiments, the transdermal pharmaceutical compositions contain progesterone, a medium-chain oil, and d-limonene. In some embodiments, the transdermal pharmaceutical compositions contain progesterone, a medium-chain oil, a penetration enhancer (e.g., propylene glycol, a fatty acid ester of propylene glycol, a glycol ether), and optionally d-limonene. In certain embodiments, the pharmaceutical compositions further include estradiol. Methods for treating conditions associated with hormone deficiency in a subject are also described.

Transdermal cream

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Stuart, FL, United States of America

Jason D Legassie