Smithkline Beecham Corporation

Other

Affinium Pharmaceuticals, Inc.

Jason Craig Fedon

Leslie Marie Palmer

Richard Lloyd Warren

John Edward Hodgson

Michael Arthur Lonetto

Richard Oakley Nicholas

Michael Terence Black

Christopher Michael Traini

Martin M Rosenberg

Raymond Winfield Reichard

Judith M Ward

Julie M Pratt

David Justin Charles Knowles

Lisa Kathleen Shilling

Min Wang

Deborah Dee Jaworski

David Justin Knowles

Robert King Stodola

Christine Marie Debouck

Jeffrey L Mooney

Anna Lisa Kosmatka

Martin Karl Russell Burnham

Yi Yi Zhong

Martin Karl Burnham

Nicola Gail Wallis

Howard Kallender

Magdalena Zalacain

David John Holmes

Sanjoy Biswas

Stephanie Van Horn

Karen Anne Ingraham

John Timothy Lonsdale

Chi Young So

Karen M O'Dwyer

Martin K R Burnham

Anna Lisa Lenox

Marie J Mazzulla

Glenn Scott Van Aller

Yi Y Zhong

Michael Terance Black

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.

UDP-N-acetylenolpyruvylglucosamine reductase

The invention provides RncS polypeptides and DNA (RNA) encoding RncS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RncS polypeptides to screen for antibacterial compounds.

Polynucleotides encoding a ribonuclease s

The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.

ribG

The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.

RibH

The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.

Polynucleotides encoding GTP cyclohydrolase II (RIBA)

Ribb

The invention provides gidA1 polypeptides and polynucleotides encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidA1 polypeptides to screen for antibacterial compounds.

GidA1

UDP-N-acetylenolpyruvyglucosamine reductase

GTP cyclohydrolase II (RIBA)

ribH

The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.

FabF

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Strafford, PA, United States of America

Jason Craig Fedon