Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Jason Christopher Wong

Xihan Wu

Chungen Liang

Guozhi Tang

Li Chen

Tao Guo

Hongying Yun

Lisha Wang

Lichun Feng

Yongfu Liu

Xiufang Zheng

Lu Gao

Song Feng

Jim Zhen Wu

Mengwei Huang

Zhenshan Zhang

Yun He

Weixing Zhang

Lei Guo

Xianfeng Lin

Zongxing Qiu

Zhanguo Wang

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein Rto R, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.

Compounds for the treatment and prophylaxis of respiratory syncytial virus disease

Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein Rto Rand X have the significances given herein. The present invention is also directed to processes for making said compounds and uses of said compounds, in particular their use as medicaments, more particularly their use as medicaments in the treatment of cancer.

N-hydroxy-benzamids for the treatment of cancer

The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein Rto R, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.

4-amino-N-hydroxy-benzamides for the treatment of cancer

The present invention is directed to a compound of formula I, and processes for the manufacture of said compounds as well as medicaments containing said compound. The compounds according to this invention show anti-proliferative and differentiation-inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.

Ortho-aminoanilides for the treatment of cancer

The present invention is directed to the compounds of formula wherein Rto Rhave the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds according to this invention show anti-proliferative and differentiation-inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.

N-(2-amino-phenyl)-acrylamides

Compounds of formula are HDAC inhibitors. These compounds are useful for the treatment of diseases such as cancer in humans or animals.

Ortho aminoamides for the treatment of cancer

The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments containing such compounds. The compounds of the present invention show anti-proliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion. The invention also covers the use of such compounds for the treatment of diseases such as cancer and for the manufacture of corresponding medicaments.

N-(2-amino-phenyl)-amide derivatives

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Shanghai, China

Jason Christopher Wong