Malvern Panalytical Inc.

Malvern Instruments Limited

Jason Cecil William Corbett

Malcolm Connah

Kevin Mattison

David Bryce

David Stringfellow

Rhys Poolman

Nigel Lightfoot

In one general aspect, an electrophoretic measurement method is disclosed that includes providing a vessel that holds a dispersant, providing a first electrode immersed in the dispersant, and providing a second electrode immersed in the dispersant. A sample is placed at a location within the dispersant between the first and second electrodes with the sample being separated from the electrodes, an alternating electric field is applied across the electrodes, and the sample is illuminated with temporally coherent light. A frequency shift is detected in light from the step of illuminating that has interacted with the sample during the step of applying an alternating electric field, and a property of the sample is derived based on results of the step of detecting.

Laser doppler electrophoresis using a diffusion barrier

Method of characterizing particles suspended in a fluid dispersant by light diffraction, comprising: obtaining measurement data from a detector element, the detector element being arranged to measure the intensity of scattered light; identifying a measurement contribution arising from light scattered by inhomogeneities in the dispersant; processing the measurement data to remove or separate the measurement contribution arising from light scattered by inhomogeneities in the dispersant; calculating a particle size distribution from the processed measurement. The detector element is one of a plurality of detector elements from which the measurement data is obtained. The detector elements are arranged to measure the intensity of scattered light at a plurality of scattering angles, the plurality of scattering angles distributed over a plurality of angles about an illumination axis. Identifying a measurement contribution arising from light scattered by inhomogeneities in the dispersant comprises identifying measured scattered light that is asymmetric about the illumination axis.

Thermal compensation

A particle characterisation apparatus comprising: a light source for illuminating a sample with a light beam; a detector arranged to detect scattered light from the interaction of the light beam with the sample; a focus tuneable lens arranged to collect the scattered light for the detector from a scattering volume and/or to direct the light beam into the sample, a sample holder with an opposed pair of electrodes and configured to hold a sample in position in a measurement volume between the pair of electrodes such that a planar surface of the sample is aligned orthogonally to the electrode surfaces, the planar surface adjacent to the scattering volume, wherein adjustment of the focus tuneable lens results in adjustment of the relative position of the planar surface and the scattering volume by moving the scattering volume.

Particle characterisation with a focus tuneable lens

A particle characterization apparatus comprising: a light source for illuminating a sample with a light beam; a detector arranged to detect scattered light from the interaction of the light beam with the sample; and a focus tuneable lens arranged to collect the scattered light for the detector from a scattering volume and/or to direct the light beam into the sample.

Particle characterization

A particle characterization apparatus is disclosed comprising: a sample cell for holding a sample, a light source for producing a light beam for illuminating the sample in the sample cell, thereby producing scattered light by the interaction of the light beam with the sample; a focussing lens for focussing the light beam within the sample; and a detector for detecting the backscattered light along a detection optical path that intersects the focussed light beam within the sample. The intersection of the light beam and the detection optical path in the sample define a detection region. The apparatus comprises an optical arrangement for varying the volume of the detection region.

An instrument and a method for measuring the characteristics of particles in a sample. The instrument comprises a light source operable to provide a light beam and defining an illumination axis; a sample cell placed on the illumination axis; a scattered light detector positioned to receive scattered light along a detection path from a sample in the sample cell, the scattered light produced by the interaction of the light beam with the sample; and a filter changer positioned between the sample cell and the scattered light detector. The filter changer comprises at least one optical filter and an actuator. The actuator is operable to move each of the at least one optical filter between a first position in which the detection path does not pass through the optical filter, and a second position in which the detection path passes through the optical filter.

Particle characterisation instrument

In one general aspect, a method of measuring characteristics of particles in a liquid sample is disclosed. The method includes suspending the liquid sample in a tube. The suspended liquid sample is illuminated along an illumination axis, and at least a portion of the light is detected along a first detection axis after it is scattered by the particles in the suspended liquid sample. The illumination axis and the detection axis are oriented at an angle with respect to each other.

In one general aspect, a method of measuring characteristics of particles in a liquid sample disclosed. The method includes supporting the liquid sample by surface tension and illuminating the supported liquid sample along an illumination axis with spatially coherent light so as to cause the coherent light to be scattered across a scattering zone. At least a portion of the scattered light is detected along a first predetermined scattering detection axis after it is scattered by the particles in the supported liquid sample. The illumination axis and the detection axis are oriented at an angle with respect to each other that allows substantially all of the light scattered at that angle across the scattering zone to be detected.

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Malvern, United Kingdom

Jason Cecil William Corbett