University of California

New York University

Virginia Commonwealth University

Other

University of Bristol

Jason C Reed

James K Gimzewski

Bhubaneswar Mishra

Michael A Teitell

Andrey Mikheykin

Andrew Sundstrom

Freddie Russell-pavier

Loren Picco

Oliver Payton

Exemplary embodiments of the present disclosure can include, for example, an atomic force microscopy (AFM) system, including a cantilever(s), an optical pickup unit(s) (OPU(s)) including a laser positioned over the cantilever(s), and a power source providing noise with a noise level that is below 300 Picometers. The noise level of the power source can be below 200 Picometers. A digitizing arrangement can be included which can be associated with the OPU. The digitizing arrangement(s) can have a bandwidth of about 2 MHZ. The OPU(s) can have a detection bandwidth of at least 80 MHZ. The exemplary apparatus can be combined with a chemical protocol and statistical signal processing and image analysis procedures to map DNA at high speed and accuracy.

System, method, computer-accessible medium and apparatus for DNA mapping

A training apparatus for baseball training includes a base and training attachments that may be attached to the base to allow a user to practice a variety of training techniques. The base may be modular so that it has an adjustable width and disassembles into separate components. At least one training attachment is designed to train a batter to properly incorporate thrust into a swinging motion when swinging a baseball bat. The attachment has a pivotally mounted member with a contact element attached to the top end of the member. The member pivots forward and downward when the user's knee contacts the contact element when properly executing a swinging motion. Thus, the training attachment provides direct and immediate feedback to the user regarding the user's batting form. Other training attachments may be used for hitting balls and for pitching to targets strategically placed around a strike zone.

Sports training device, system, and method of use

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

Optical cytometry to determine cell mass changes in response to a biologically active agent

The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.

Compositions and methods for analyzing immobilized nucleic acids

A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.

Single cell drug response measurements via live cell interferometry

An exemplary system, method and computer-accessible medium can be provided for generating an encrypted reference-based secure-compression of randomly located short sequence reads from a genome(s), which can, for example, including obtaining information related to the randomly located short sequence reads, obtaining second information related to a plurality of reference sequences for the genome(s), generating third information related to a set of edit calls containing location information based on the first and second information using a base-calling procedure and an alignment procedure, and generating the encrypted reference-based secure-compression of the first information based on the third information. The exemplary system, method and computer-accessible medium can facilitate the exemplary chemistry box to generate analog information to be locally and physically separated from informatics box interpreting digital data.

System, method and computer-accessible medium for secure and compressed transmission of genomic data

The present disclosure provides methods of measuring a property of a macromolecule. The methods generally involve applying an empirically learned correction term to a test metric to generate a high-accuracy measurement. The present disclosure further provides a computer program product and a computer system for carrying out a subject method.

Methods and systems for measuring a property of a macromolecule

A complex mixture is analyzed for multiple nucleic acid sequences (e.g., DNA or RNA sequences) simultaneously by target specific multiplex amplification followed by single molecule detection of amplicons by Atomic Force Microscopy (AFM). The presence or absence of target nucleic acids can be determined from the presence or absence of specific amplicons for those nucleic acids. In addition, quantification of target nucleic acids in the complex mixture is achieved by determination of the numbers of amplicons.

Identification and quantification of multiple nucleic acid targets in complex mixtures

Use of live cell inteferometry with reflective floor of observation chamber to determine changes in mass of mammalian cells

Optical cytometry

The present invention provides methods of detecting a nucleic acid analyte in a sample. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.

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Los Angeles, CA, United States of America

Jason C Reed