Osi Pharmaceuticals, Inc.

Prosidion Limited

Jason Bloxham

Bijoy Panicker

An-Hu Li

Martin James Procter

Stuart Edward Bradley

Karen Lesley Schofield

Shazia Sadiq

Colin Peter Sambrook Smith

Thomas Martin Krulle

Graham Wynne

Donald Smyth

Colin Peter Sambrook-Smith

Andrew Philip Crew

Hanqing Dong

Eric W Collington

Ayako Honda

Neil Anthony Pegg

John Kitchin

Robin Wilkes

Oscar Barba

Kathryn M Stolz

Matthew Cox

William Gattrell

Lifu Ma

Amo G Steinig

Saleh Ahmed

Graham Dawson

Imaad Saba

Don Smyth

Kenneth (‘Ken’) Foreman

Qinghua (‘Felix’) Weng

Alan John Stewart

Gary V Borzillo

Tom Banksia Dupree

Chris L Waller

Peter Timothy Fry

Lawrence Tardibono, Jr

Patrick Eric Hanrahan

Paula Tavares

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity. 

Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity. 

Bicyclic aryl and heteroaryl receptor modulators

The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, X, Xand Xare as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula 1.

Integrin antagonists useful as anticancer agents

Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.

(2-carboxamido)(3-Amino) thiophene compounds

Substituted pyrrolo[2.3-B]pyridines

Growing community of inventors

Oxford, United Kingdom

Jason Bloxham