The University of Texas System

Onconano Medicine, Inc.

Jason B Miller

Daniel J Siegwart

Kejin Zhou

Philip Jordan Thomas

Lian Xue

Jing Hao

Petra Kos

Tian Zhao

Gaurav Bharadwaj

Xinliang Ding

Stephen Gutowski

Drew Robinson

Ashley Campbell

Qingtai Su

Michael J Torres

Philip J Thomas

Arthur E Johnson

The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.

Therapeutic pH responsive compositions

Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Lipocationic polymers and uses thereof

Growing community of inventors

Dallas, TX, United States of America

Jason B Miller