Becton Dickinson and Company Limited

Jason B Alarcon

John A Mikszta

John P Dekker, Iii

Frank E Martin

M Ishaq Haider

Alexander George Lastovich

Scott A O'Connor

Ronald J Pettis

Phillipe Laurent

John M Brittingham

Weston F Harding

Timothy J Erskine

Richard P Clarke

Bruce Clyde Roberts

Cheryl H Dean

Andrea Waterston

John P Dekker

John P Iii Dekker

Ishaq M Haider

A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter.

Optimized intracranial catheters for convection-enhanced delivery of therapeutics

Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.

Microprotrusion arrays and methods for using same to deliver substances into tissue

The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.

Topical delivery of vaccines

An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.

Method and device for the delivery of a substance

The present invention relates to methods and devices for administration of vaccines and gene therapeutic agents into the intradermal layer of skin.

Intradermal delivery of vaccines and gene therapeutic agents via microcannula

An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.

Microabrader with controlled abrasion features

Method and device for the delivery of a substance including a covering

A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions which may be imparted by a spring device present in the microabrader device or the motion of the operator through the handle of the microabrader device. The device may further include system and methods for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The delivered substance may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.

Substance delivery via a rotating microabrading surface

A method for delivering a substance to the epidermal tissue of skin. The method involves simultaneously disrupting only the stratum corneum of the skin and delivering the substance to the epidermal tissue of the skin.

Growing community of inventors

Durham, NC, United States of America

Jason B Alarcon