Tufts University

Duke University

University of Pennsylvania

University of Illinois

Northwestern University

The University of Arizona

Jason Amsden

David L Kaplan

Fiorenzo G Omenetto

John A Rogers

Yonggang Huang

Michael E Gehm

Jonathan Viventi

David Brady

Brian Litt

Dae-Hyeong Kim

Charles B Parker

Jeffrey T Glass

Michele Muccini

Raffaella Capelli

M Bonner Denton

Roger P Sperline

Stefano Toffanin

Roberto Zamboni

Valentina Benfenati

Shane Di Dona

Evan Chen

Rafael Bento Serpa

Charles Parker

Scott Tilden

Zach Russell

Elettra Piacentino

Justin Keogh

Rob Kingston

A virtual slit cycloidal mass spectrometer and spectrometry methods are disclosed. The spectrometer size-selects particles, which in turn serve as a 'virtual slit' for a cycloidal mass analyzer. This virtual slit provides unprecedented resolution in a system that takes up a much smaller physical footprint than was previously achievable. This spectrometer may facilitate field sampling of isotopes, such as uranium isotopes.

Virtual slit cycloidal mass spectrometer

Disclosed herein are mass spectrometers having segmented electrodes and associated methods. According to an aspect, an apparatus or mass spectrometer includes an ion source configured to generate ions from a sample. The apparatus also includes a detector configured to detect a plurality of mass-to-charge ratios associated with the ions. Further, the apparatus includes segmented electrodes positioned between the ion source and the detector. The apparatus also includes a controller configured to selectively apply a voltage across the segmented electrodes for forming a predetermined electric field profile.

Mass spectrometers having segmented electrodes and associated methods

Aspects of the present disclosure describe systems, methods, and structures for compound-specific coding mass spectrometry wherein compound-specific masks/codes are positioned between an ion source and detector of a mass spectrometer.

Systems, methods, and structures for compound-specific coding mass spectrometry

Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment.

Implantable biomedical devices on bioresorbable substrates

The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass transition temperature of the silk film. Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.

Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications

The invention relates to ecosustainable and biocompatible, low cost, ambient friendly electronic and optoelectronic devices, such as transistors and light-emitting transistors, made with silk fibroin or blended with other biopolymers, methods for fabrication and methods of using the silk-based electronics and optoelectronics. The silk-based electronics and optoelectronics can be implanted in vivo and in vitro for biomedical applications, such as for drug discovery or drug screening assays and devices. The silk-based devices may be used in the food industry and embedded in packaging for tracking and sensing, for security purposes or exploited as disposable not harmful for the environment efficient general electronic and optoelectronic devices.

Silk transistor devices

Provided herein are implantable biomedical devices, methods of administering implantable biomedical devices, methods of making implantable biomedical devices, and methods of using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. Each implantable biomedical device comprises a bioresorbable substrate, an electronic device having a plurality of inorganic semiconductor components supported by the bioresorbable substrate, and a barrier layer encapsulating at least a portion of the inorganic semiconductor components. Upon contact with a biological environment the bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between the implantable biomedical device and the target tissue in the biological environment.

Growing community of inventors

Durham, NC, United States of America

Jason Amsden