Monsanto Technology LLC

Research Development Foundation

Jason A Wicker

Tyamagondlu V Venkatesh

Jihong Liang

Tim N Oulmassov

Kairong Tian

William D Rapp

William J Welsh

Xia Wang

Robert K DeLisle

Melissa C Whiteman

Michael D T Barrett

Methods and compositions concerning mutant flaviviruses with reduced virulence. In some embodiments the invention concerns nucleotide sequences that encode mutant flaviviral proteins. Viruses comprising mutant NS1 and NS4B genes display reduced virulence are provided. In further aspects of the invention, flavivirus vaccine compositions such as West Nile virus vaccines are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.

Attenuated virus strains and uses thereof

The present invention generally relates to the field of plant genetics and protein biochemistry. More specifically, the present invention relates to modified proteins having an increased number of essential amino acids. The present invention provides proteins modified to have an increased number of essential amino acids, nucleic acid sequences encoding the enhanced proteins, and methods of designing, producing, and using the same. The present invention also includes compositions, transformed host cells, transgenic plants, and seeds containing the enhanced proteins, and methods for preparing and using the same.

Enhanced proteins and methods for their use

Growing community of inventors

Galveston, TX, United States of America

Jason A Wicker