Alphora Research Inc.

Sandoz Ag

Jason A Bexrud

Boris Gorin

Ricardo Orprecio

Fabio E S Souza

Ming Pan

Alena Rudolph

Huzaifa Rangwala

Teng Ko Ngooi

Fabio Es Souza

Fabio ES Souza

Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed. 

Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein

Discloses is a process for preparation of a compound of formula 11, or a derivative thereof, wherein PGis an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 11 can be useful in the preparation of halinchondrin analogs. 

3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof

Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PGis an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 7 can be useful in the preparation of halinchondrin analogs such as Eribulin. 

Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof

Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof

Growing community of inventors

Toronto, Canada

Jason A Bexrud