Variation Biotechnologies Inc.

Jasminka Bozic

David E Anderson

Barthelemy Ontsouka

Marc J Kirchmeier

Tanvir Ahmed

Marc Kirchmeier

David Anderson

The present disclosure provides compositions and methods useful for treating viral infections. As described herein, the compositions and methods are based on the development of immunogenic compositions that include an attenuated or inactivated virus in combination with a non-ionic surfactant vesicle (NISV).

Compositions and methods for treating viral infections

The present disclosure provides methods useful for determining levels of HCMV infection in host cells and, by extension, determining levels of neutralizing antibodies present in a sample. The present disclosure encompasses the recognition that HCMV viruses that have a fluorescent moiety permit detection of viral infection (e.g., by assessing fluorescence in cells after contacting the host cell with the virus). In some embodiments, levels of HCMV infection are determined by fluorescence detection where the virus has been preincubated with a test sample (e.g., a serum sample) from a subject. In some embodiments, the subject has been administered a candidate HCMV vaccine.

Methods for detection of anti-cytomegalovirus neutralizing antibodies

Growing community of inventors

Ottawa, Canada

Jasminka Bozic