Adlyfe, Inc.

System of Systems Analytics, Inc.

Cindy S. Orser

Tao Pan

Jasmeet Sethi

Cindy S Orser

The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.

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Germantown, MD, United States of America

Jasmeet Sethi