Wyeth

Jasdeep Singh Nanra

Kathrin Ute Jansen

Annaliesa Sybil Anderson

Bruce Arthur Green

Viliam Pavliak

Ingrid Lea Scully

Mark Edward Ruppen

Steven Morris Baker

Ellen Murphy

A Krishna Prasad

Ingrid Lea Dodge

Yekaterina Timofeyeva

Stephen John Freese

Tracy Dee Scott

Annaliesa Anderson

The present invention relates to immunogenic conjugates comprisingserotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

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The present invention relates to immunogenic conjugates comprisingserotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from. The present invention also relates to immunogenic compositions, comprisingcapsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects againstusing immunogenic compositions of thepolypeptides and capsule polysaccharides.

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Suffern, NY, United States of America

Jasdeep Singh Nanra