Amicrobe, Inc.

University of California

Jarrod A Hanson

Michael P Bevilacqua

Diego Benitez

Timothy J Deming

Lucas Koziol

Diego Bentitez

Thomas G Mason

Connie B Chang

Sara M Graves

Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.

Compositions and uses of antimicrobial materials with tissue-compatible properties

Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.

Composition with high antimicrobial activity and low toxicity

Compositions and uses of materials with high antimicrobial activity and low toxicity

An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid having an inner surface contained within the outer surface of the outer droplet of the first liquid, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the inner surface of the inner droplet. The block copolymers include a hydrophilic polymer block and a hydrophobic polymer block that act in combination to stabilize the droplet structure, and the first liquid is immiscible in the substantially continuous liquid medium.

Copolymer-stabilized emulsions

Growing community of inventors

Los Angeles, CA, United States of America

Jarrod A Hanson