Ciba-Geigy Corporation

Novartis Ag

Jaroslav Stanek

Jorg Frei

Gerhard Baschang

Albert Hartmann

Giorgio Caravatti

Lajos Tarcsay

Hans-Georg Capraro

Marc Lang

Edmond Differding

Roland Gisler

Felix M Dietrich

Daniel Bellus

Alberto Rossi

Alex Alder

Alex Sele

Oskar Wacker

Bruno Kamber

Ernst Schweizer

J Org Frei

Imidazole derivatives, their preparation and their use as

Piperidinyl-2-alkyl, substituted linear polyamines for the reduction of

Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

Hydrazones

Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

.alpha.-fluoro-.alpha.-1-(1,2,4-triazolyl)-phenylmethyl derivatives

Unsaturate amino compounds for use as anticancer and antiprotozoic agent

Ornithine decarboxylase inhibiting branched aminooxy amino alkane

Ornithine decarboxylase inhibiting cyclic aminooxy compounds

4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile

Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.

Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.

.alpha.-fluoro-.alpha.-(1,2,3-triazolyl)-phenylmethyl derivatives useful

Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.

Arylhydrazones using as SAMDC inhibitors

Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a manner known per se.

Bipyridyls

The invention relates to compounds of formula I ##STR1## wherein either R.sub.1 is a radical of formula Ia,

Aminooxy piperidines as ornithine decarboxylase inhibitors

Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

Arylhydrazones and pharmaceutical compositions thereof

.alpha.-fluoro-.alpha.-tetrazolyl-phenylmethyl derivatives useful as

Growing community of inventors

Arlesheim, Switzerland

Jaroslav Stanek