Ludwig Heumann & Co. Gmbh

Jaroslav Prikryl

Walter Otto Liebenow

Edgar Fritschi

A compound selected from a 2,4-diamino-5-thiobenzylpyrimidine of the formula: ##STR1## in which R is selected from hydrogen, alkyl, lower alkoxy, and halogen and R' is alkyl; and pharmacologically acceptable acid addition salts thereof. These compounds have an anti-bacterial action and are sulphonamide potentiators.

2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions

A process for the production of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine by condensing trimethoxy benzaldehyde with a substituted propionitrile compound and reacting the condensation product obtained with guanidine, wherein a .beta.-akyl-(aryl-, benzyl-)-oxy-ethyleneoxy-propionitrile corresponding to the formula

Process for the production of

Bactericidal 4'-alkyldioxyalkylene-5-benzylpyrimidines, process for their production, and pharmaceutical compositions or formulations thereof, containing compounds of the general formula: ##SPC1## Wherein R.sub.1 is an alkyl group containing from 1 to 3 carbon atoms, R is an atom of hydrogen, an atom of halogen, or an alkyl or alkoxy group containing from 1 to 3 carbon atoms, and n is an integer of from 1 to 3, Exhibit excellent bactericidal activity and low toxicity and are suitable for oral administration.

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Erlangen-Bruck, Germany

Jaroslav Prikryl