Abbott Laboratories Corporation

Jaroslav Kyncl

Peter Hadley Jones

Martin Winn

Daniel Ambrose Dunnigan

Carroll Wayne Ours

Yvonne Connolly Martin

Anthony K Fung

Amrit Lall

Carroll W Curs

Dilbagh Singh Bariana

Peter Handley Jones

Kathleen Riley Lynn

Pitambar Somani

Dilbagh S Bariana

This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula ##STR1## wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R.sub.1 is --CH.sub.2 COOH or methyl tetrazole, and X.sub.1 and X.sub.2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring. These compounds are useful as antihypertensive agents, diuretics and uricosuric agents.

4-Aroyl substituted phenoxy methylene-5-tetrazoles

Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazo line, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

Antihypertensive agents

This invention covers diacylated derivatives of .gamma.-glutamyl dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C.sub.1 -C.sub.7 alkyl, and a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful to increase the renal blood flow by being administered to warm-blooded animals by clinically accepted routes of administration such as oral, parenteral, rectal and the like.

Diacylated derivates of .gamma.-glutamyl dopamine

Diacylated derivatives of .gamma.-glutamyl dopamine

Disclosed are compounds of the formula ##STR1## wherein n is 2 or 3, R is hydrogen or methyl, R' is C.sub.1 -C.sub.6 alkyl, acyl, aryl, aroyl, alkoxycarbonyl, tetrahydrofuroyl, dialkylaminocarbonyl, or furoyl, and R' is hydrogen and methoxy. These compounds are useful as antihypertensive agents.

N-(2-benzimidazolyl)-piperazines

Described are the compounds 5,6-dimethoxy-2-(4-benzyl-1-piperidino) benzimidazole and 5,6-dimethoxy-2 (6,7-dimethoxy-1,2,3,4-tetrahydro 2-isoquinolinyl benzimidazole and pharmaceutically acceptable acid addition salts thereof. The compounds are useful as antihypertensive agents.

5,6-Dimethoxy-2-heterocyclic benzimidazoles

4-Aroyl-substituted phenoxy acetic acids

Described are the compounds 2[4(tetrahydro-2-furoyl)-hexahydro-1,4-diazepinyl-1]-4-amino-6,7-dimethoxy quinazoline and pharmaceutically acceptable acid addition salts thereof. The compounds are useful as antihypertensive agents.

Covers the esters of .gamma.-glutamyl amide of dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.18 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of .gamma.-glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

Esters of .gamma.-glutamyl amide of dopamine

Covers a .gamma.-glutamyl amide of dopamine selected from the group consisting of ##EQU1## and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said .gamma.-glutamyl amide to increase renal blood flow by administering said amide to warm-blooded mammals.

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Lake Bluff, IL, United States of America

Jaroslav Kyncl