Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Ustav Organicke Chemie a Biochemie Akademie Ved Cr, V.v.i.

Fyziologicky Ustav Akademie Ved Cr, V.v.i.

Fyziologicky Ustav Akademie Ved Ceske Republiky, V.v.i.

Jaroslav Kunes

Lenka Maletinska

Blanka Zelezna

Miroslava Blechova

Andrea Spolcova

Barbora Mikulaskova

Stepan Strnad

Veronika Prazienkova

Veronika Nagelova

Lipidated neuropeptides PrRP31, PrRP20, containing C14 to C16 fatty acid, and their analogs, wherein a sequence of IRPVGRF-NHat the C-terminus is variable in the site of isoleucine, valine and phenylalanine; said fatty acid is bound in position 1 or 11 for PrRP31 or its analog and in position 1 or 7 for PrRP20 or its analog; the bond comprises an amide bond between an amino acid having at least one free NHgroup and a carboxylic group of the fatty acid and alternatively includes also a binding through arm X, which is a hydrophilic linker selected from a group comprising &#x3b2;-alanine, &#x3b3;-aminobutyric acid or &#x3b3;-glutamic acid; for use in the treatment and prevention of diseases, which are Alzheimer's disease (AD), Parkinson's disease (PD), cognitive impairment no dementia (CIND), brain trauma, and neurodegenerative changes and disorders.

Lipidated peptides as neuroprotective agents

Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.

Lipidated peptides for lowering blood glucose

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Prague, Czechia

Jaroslav Kunes